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pentobarbital will reduce the extent or impact of methadone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.pentobarbital will reduce the extent or influence of atogepant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Advisable atogepant dosage with concomitant uti